May 20, 2022 4:56 pm

Covid: a mouthwash developed in Argentina would inactivate 99.9% of the virus

CÓRDOBA.— The scientific magazine Healthcare published a report in which scientists and universities from Spain, Italy, the United States, Mexico and Colombia participated, stating that a mouthwash developed in Argentina, and what does it contain D-limoneno bioencapsulado, “offers high efficacy against SARS-CoV-2.” Does not prevent the virus from entering, but inactivates it.

The mouthwash is approved by Anmat as a grade 2 oral hygiene product —in addition to the most important regulatory entities of different countries— and has been marketed since the middle of last year in the country. It was developed entirely by Brix Medical Science in Argentina and patented by Brix USA LLC. I know produces in Argentina since the middle of last year and, four months ago, under license in Mexico.

From next week it will start manufacture in Spain for all of Europe, the Middle East and Africa. The laboratory is about to close an agreement with a company in India to produce it for that country and for Southeast Asia. The trade name is Xyntrus.

Juan Ignacio Zagarí Global Business Director of Brix USA LLC, explained to LA NACION that at the beginning of the pandemic the international consultants with whom they work asked them think of a product to “take care” of dentists due to the high level of risk that their task presents. Existing products on the market had antibacterial properties, not against viral activity (those that registered it, it was at very low levels).

The laboratory carried out research with the Chair of Biochemistry and Pharmacy of the University of Buenos Aires based on the herpes simplex virus What is it “identical” to SARS-CoV-2 from the point of view of the membrane that covers it. The result of the development marked a success of 99.9%.

“It was proven that the rinse breaks the membrane in 30 seconds, the virus is exposed, inactivated, and loses the ability to replicate, infect cells, and spread from person to person”, pointed out Zagari, who emphasizes that “in no way” are they proposing that the current protocols be abandoned “but this could be added”.

The tests directly on the virus were carried out in the Simón Bolívar University of Barranquillas, in Colombia, and the efficacy demonstrated was the same.

The study of Healthcare bears the signatures of Héctor Rodríguez-Casanovas; Manuel de la Rosa; Yesit Bello-Lemus; Giulio Rasperini and Antonio J. Acosta-Hoyos. The scientists conclude that the mouthwash “destroys the phospholipid membrane of the virus with an efficiency greater than 99.99, inactivating it and thus, it causes it to lose its ability to replicate, infect cells and be transmitted through droplets of saliva”.

The saliva of patients with Covid-19 contains a high viral load of SARS-CoV-2 virus and the risk of spread is very high. In the published study, positive Covid-19 nasopharyngeal swabs were used, measured by RT-PCR for virus activity in a 1:1 ratio, with an incubation time of one minute.

The study compared different formulations of mouthwashes and “it was shown that bioencapsulated D-limonene is responsible for more than 95% of the effectiveness.” The text indicates that “once the rinse has been carried out for 30 seconds, the viral load in the mouth decreases for up to five hours thanks to the substantivity of its components.”

For the signatories of the report, the findings would be “extrapolated to all variants of SARS-CoV-2, which are of concern to the international scientific community since they increase the transmission of the virus that causes Covid-19.”

The Spaniard Rodríguez Casanovas considers that demonstrate the efficacy of bioencapsulated D-limonene with EBE Technology against SARS-CoV-2 is “very important” since “currently variants such as the omicron are of great concern” due to their “high transmissibility, generating contagion through droplets of saliva”.

THE NATION consulted three Argentine infectologists on the subject who agreed to state that they do not know the subject, but that the approval of the Anmat specifies what its use is, that is, oral hygiene. It is not a specific medication for Covid, beyond the results that the international study shows.

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